Projects｜j-CCRC Japan Consortium of Clinical Research Core Hospitals

Research subjectInstitutionArea of the studyDevelopment itemsRegulatory approval

Diffusion-Weighted Magnetic REsonance Imaging Assessment of Liver Metastasis to Improve Surgical Planning (EORTC-1527-GITCG-IG/ JCOG1609INT, DREAM)National Cancer Center HospitalCancerMedical devicesOthers

Study
outline
To evaluate the diagnostic performance of multi-parametric MRI to predict the nature of confirmed disappearing liver metastases (cDLMs) that were either resected or left behind after surgery using histopathology and imaging within two years of the initial surgery, respectively, as the best available reference of true lesion status
* In this study, "cDLMs" are defined as lesions not detected on both pre-operative CT scan and multiparametric MRI [DW-MRI, T1/T2 and CE-MRI (either hepatocyte specific and or extracellular)]
A Randomized, Double-Blind, Phase III Study Comparing FTD/TPI Therapy Versus Placebo in Patients Who Are Positive for Blood Circulating Tumor DNA After Curative Resection of Colorectal CancerNational Cancer Center Hospital EastCancerDrugsOff-label use

Study
outline
This trial will be conducted in patients who underwent curative resection of colorectal cancer and then tested positive in monitoring using SignateraTM assay for detecting blood circulating tumor DNA (ctDNA) for the detection of molecular residual tumor, with no apparent relapse on imaging. The objective of the trial is to verify the efficacy and safety of preemptive treatment with trifluridine/tipiracil hydrochloride (FTD/TPI) compared with matching placebo.
Phase 2 clinical trial with the combination of sulfasalazine and anticancer drugs for liver-fluke induced cholangiocarcinoma in ThailandKeio University HospitalCancerDrugsOff-label use

Study
outline
A phase 2 clinical trial in which sulfasalazine, a cancer stem cell therapeutic drug, is used in addition to the comventional anticancer drug treatment for liver fluke-induced cholangiocarcinoma, which is a serious health problem in Thailand.
Collaborating study of Prospective, MUlticenteR, Observational StUdy of the PatIenTs with Heart Failure with Preserved Ejection Fraction (PURSUIT HFPEF) between Japan and CambodiaOsaka University HospitalOther than cancerOtherOthers

Study
outline
Osaka University Hospital and affiliating hospitals has been conducting heart failure with preseved ejection fraction (HFpEF) registry aiming to clarify patients characteristics, treatment and long-term outcomes. We are plannning to conduct collaborating study of HFpEF registry between Japan and Cambodia.
New Treatment Development for Sleeping Sickness, a neglected tropical disease. - The new drug candidate inhibiting protozoan cyan-resistant respiratory enzyme -Osaka University HospitalOther than cancerDrugsUnapproved

Study
outline
Sleeping sickness, or human African trypanosomiasis, is a life-threatening vector borne disease caused by related parasite strains, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. If not treated, people develop neuropsychiatric symptoms. If left untreated, sleeping sickness is usually fatal.The researcher found the compound inhibit parasites’ cyan-resistant respiration and could save infected animals in experimental model.
Global Clinical Trial for Primary Triglyceride Deposit Cardiomyovasculopathy (TGCV) with CNT-02Osaka University HospitalOther than cancerOtherOthers

Study
outline
Primary Triglyceride Deposit Cardiomyovasculopathy (TGCV) is a rare disease in cardiovascular medicine caused by Adipose triglyceride lipase (ATGL) deficiency that was found by Prof. Hirano. Medium chain fatty acid may be a promising durg to improve outcomes.
Formation of ’Collaborative Research Network for Asian Children with Developmental Disorders (CRNACDD)’Osaka University HospitalOther than cancerOtherOthers

Study
outline
Most big data, scales and Interventions for neurodevelopmental disorders (NDDs) have been developed in Western countries. Different lifestyles(ex. sleep habits) in Asia from Western Countries as well as regional, cultural and social characteristics of Asia may affect the symptoms of NDDs. Less availability of resources, educational program, human resources for NDDs in Asia. Need collaboration among Asian institutes of NDDs.

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